by soschnei
Last Updated February 13, 2018 12:19 PM

I need to calculate the minimal detectable change (MDC) for my dataset and found the following formula in several publications:

$MDC = 1.96 * SD * \sqrt(1-ICC) * \sqrt2$

They argue $\sqrt2$ is used, because of the uncertainty of two measurement timepoints. However, in my dataset I don't have just test-retest measurement, but indeed 7 different measurement timepoints, based on which I need to calculate the MDC. Do I need to exchange $\sqrt2$ by $\sqrt7$?

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